I can't really say what preconception I'd have of it, because I've known for a while that you were writing a book with that title and so my preconceptions of what a book with that title would be like are all mixed up with my preconceptions of what a book from you would be like. But I think that as others have said, I'd expect it to be humorous and I'd hope it was in a self-aware kind of way, rather like DWJ's The Tough Guide to Fantasyland, and probably appropriate for the YA crowd even if not marketed directly at them.